Assay
Age
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Immunohistochemistry (whole mount)
2.5 DPC
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Sox2 SRY (sex determining region Y)-box 2 (Synonyms: lcc, Sox-2, ysb) | |
Results | Reference |
1* | J:81180 Avilion AA, Nicolis SK, Pevny LH, Perez L, Vivian N, Lovell-Badge R, Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 2003 Jan 1;17(1):126-40 |
1* | J:284140 Frum T, Watts JL, Ralston A, TEAD4, YAP1 and WWTR1 prevent the premature onset of pluripotency prior to the 16-cell stage. Development. 2019 Sep 6;146(17):dev179861 |
1 | J:344071 Li L, Lai F, Hu X, Liu B, Lu X, Lin Z, Liu L, Xiang Y, Frum T, Halbisen MA, Chen F, Fan Q, Ralston A, Xie W, Multifaceted SOX2-chromatin interaction underpins pluripotency progression in early embryos. Science. 2023 Dec 15;382(6676):eadi5516 |
1* | J:175285 Pan H, Schultz RM, Sox2 modulates reprogramming of gene expression in two-cell mouse embryos. Biol Reprod. 2011 Aug;85(2):409-16 |
1* | J:205532 Wang S, Xia P, Ye B, Huang G, Liu J, Fan Z, Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013 Nov 7;13(5):617-25 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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